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A second clinical and echocardiographic examination was performed after a total of 45 minutes from caffeine assumption in group 1, after 15 minutes from beginning of cigarette smoking in group 2, and after 45 minutes from caffeine assumption (i.e., 15 minutes from beginning of cigarette smoking) in group 3

Review/Action The substantive review phase (Phase 3) includes evaluation of the scientific information and data in an application

It also increases the occurrence of oral leukoplakia, which are precancerous white lesions in the mouth that may progress into oral cancer

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